Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

This review summarizes recent literature (2000–2015) on the synthesis and pharmaceutical
properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring …

In 1985 the first lamellarins were isolated from a small oceanic sea snail. Today, more than
50 lamellarins have been inventoried and numerous derivatives synthesized and tested as …

Photoactivated chemotherapy (PACT) is a promising cancer treatment modality that kills
cancer cells via photochemical uncaging of a cytotoxic drug. Most ruthenium‐based …

Fused heterocycles are reported to demonstrate variety of biological activities such as
anticancer, antibacterial, antifungal and anti-inflammatory, and are thus exhaustively utilized …

A steric scale of 20 recurrent groups was established from comparison of rotational barriers
on N-(o-substituted aryl) thiazoline-2-thione atropisomers. The resulting energy of activation …

This review covers recent literature from 2012-2019 concerning 170 marine natural products
and their semisynthetic analogues with strong anticancer biological activities. Reports that …

Glioblastoma, the most common form of malignant primary brain tumor, is characterized by
resistance to apoptosis, which is largely responsible for the low effectiveness of the classical …

Cell division cycle phosphatases CDC25 A, B and C are involved in modulating cell cycle
processes and are found overexpressed in a large panel of cancer typology. Here, we …

Glioblastoma (GBM) is one of the deadliest tumors and has a median survival of 3 months if
left untreated. Despite advances in rationally targeted pharmacological approaches, the …