The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP …
D Jin, J Guo, Y Wu, L Yang, X Wang, J Du, J Dai… - Molecular Cancer, 2020 - Springer
Background The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis,
decay, and translation control is an emerging research focus. Ectopically activated YAP is …
decay, and translation control is an emerging research focus. Ectopically activated YAP is …
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
B Tang, Y Yang, M Kang, Y Wang, Y Wang, Y Bi, S He… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor
diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic …
diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic …
N6-methyladenosine links RNA metabolism to cancer progression
Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …
development of antibody-based sequencing technologies and the findings of m6A-related …
Mechanism of RNA modification N6-methyladenosine in human cancer
Z Zhou, J Lv, H Yu, J Han, X Yang, D Feng, Q Wu… - Molecular cancer, 2020 - Springer
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA
modifications has gained increasing interest in the scientific community. The discovery of N6 …
modifications has gained increasing interest in the scientific community. The discovery of N6 …
YTH Domain: A Family of N6-Methyladenosine (m6A) Readers
Like protein and DNA, different types of RNA molecules undergo various modifications.
Accumulating evidence suggests that these RNA modifications serve as sophisticated codes …
Accumulating evidence suggests that these RNA modifications serve as sophisticated codes …
Gene expression regulation mediated through reversible m6A RNA methylation
Cellular RNAs carry diverse chemical modifications that used to be regarded as static and
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …
having minor roles in'fine-tuning'structural and functional properties of RNAs. In this Review …
The biological function of m6A demethylase ALKBH5 and its role in human disease
J Wang, J Wang, Q Gu, Y Ma, Y Yang, J Zhu… - Cancer cell …, 2020 - Springer
Abstract Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is
dysregulated and acts as a biological and pharmacological role in human cancers or non …
dysregulated and acts as a biological and pharmacological role in human cancers or non …
m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells
S Huff, SK Tiwari, GM Gonzalez, Y Wang… - ACS Chemical …, 2021 - ACS Publications
N 6-methyladenosine (m6A) has emerged as the most abundant mRNA modification that
regulates gene expression in many physiological processes. m6A modification in RNA …
regulates gene expression in many physiological processes. m6A modification in RNA …