Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Mechanisms of long noncoding RNA function in development and disease
SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …
functions. Deep sequencing recently facilitated the discovery of thousands of novel …
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo
D Andergassen, JL Rinn - Nature Reviews Genetics, 2022 - nature.com
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
MEG3 noncoding RNA: a tumor suppressor
Y Zhou, X Zhang, A Klibanski - Journal of molecular …, 2012 - jme.bioscientifica.com
Maternally expressed gene 3 (MEG3) is an imprinted gene belonging to the imprinted DLK1–
MEG3 locus located at chromosome 14q32. 3 in humans. Its mouse ortholog, Meg3, also …
MEG3 locus located at chromosome 14q32. 3 in humans. Its mouse ortholog, Meg3, also …
Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells
We compared two genetically highly defined transgenic systems to identify parameters
affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that …
affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that …
MEG3 imprinted gene contribution in tumorigenesis
L Benetatos, G Vartholomatos… - International journal of …, 2011 - Wiley Online Library
Abstract Maternally expressed gene 3 (MEG3) is a maternally expressed imprinted gene
representing a large noncoding RNA in which microRNAs (miRNAs) and small nucleolar …
representing a large noncoding RNA in which microRNAs (miRNAs) and small nucleolar …
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis
L Benetatos, E Hatzimichael, E Londin… - Cellular and molecular …, 2013 - Springer
The mammalian genome is transcribed in a developmentally regulated manner, generating
RNA strands ranging from long to short non-coding RNA (ncRNAs). NcRNAs generated by …
RNA strands ranging from long to short non-coding RNA (ncRNAs). NcRNAs generated by …
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells
The generation of induced pluripotent stem cells (iPSCs) often results in aberrant epigenetic
silencing of the imprinted Dlk1-Dio3 gene cluster, compromising the ability to generate …
silencing of the imprinted Dlk1-Dio3 gene cluster, compromising the ability to generate …
Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions
UV cross-linking and immunoprecipitation (CLIP) and individual-nucleotide resolution CLIP
(iCLIP) are methods to study protein-RNA interactions in untreated cells and tissues. Here …
(iCLIP) are methods to study protein-RNA interactions in untreated cells and tissues. Here …
Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy
Background: Maternal smoking during pregnancy is associated with significant infant
morbidity and mortality, and may influence later disease risk. One mechanism by which …
morbidity and mortality, and may influence later disease risk. One mechanism by which …