Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

[HTML][HTML] Programming assembly of biomimetic exosomes: an emerging theranostic nanomedicine platform

X Xu, L Xu, C Wen, J Xia, Y Zhang, Y Liang - Materials Today Bio, 2023 - Elsevier
Exosomes have emerged as a promising cell-free therapeutic approach. However,
challenges in large-scale production, quality control, and heterogeneity must be overcome …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Methods of the large-scale production of extracellular vesicles

V Syromiatnikova, A Prokopeva… - International Journal of …, 2022 - mdpi.com
To date, extracellular vesicles (EVs) have been extensively investigated as potential
substitutes for cell therapy. Research has suggested their ability to overcome serious risks …

Technological advances towards extracellular vesicles mass production

A Grangier, J Branchu, J Volatron, M Piffoux… - Advanced Drug Delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are becoming essential actors in bio-therapeutics, as much for
their regenerative or immunomodulatory properties as for their potential as cargo delivery …

Extracellular vesicle-based therapeutics: preclinical and clinical investigations

NL Klyachko, CJ Arzt, SM Li, OA Gololobova… - Pharmaceutics, 2020 - mdpi.com
Drug nanoformulations hold remarkable promise for the efficient delivery of therapeutics to a
disease site. Unfortunately, artificial nanocarriers, mostly liposomes and polymeric …

Nanocomplexes of doxorubicin and DNA fragments for efficient and safe cancer chemotherapy

SN Mohammad, YS Choi, JY Chung, E Cedrone… - Journal of Controlled …, 2023 - Elsevier
Cancer-targeted therapy by a chemotherapeutic agent formulated in a nanoscale platform
has been challenged by complex and inefficient manufacturing, low drug loading, difficult …

[HTML][HTML] Toward the next-generation phyto-nanomedicines: Cell-derived nanovesicles (CDNs) for natural product delivery

C Chen, J Wang, M Sun, J Li, HMD Wang - Biomedicine & …, 2022 - Elsevier
Phytochemicals are plant-derived bioactive compounds, which have been widely used for
therapeutic purposes. Due to the poor water-solubility, low bioavailability and non-specific …

Synthetically engineered adeno-associated virus for efficient, safe, and versatile gene therapy applications

ML Lugin, RT Lee, YJ Kwon - ACS nano, 2020 - ACS Publications
Gene therapy directly targets mutations causing disease, allowing for a specific treatment at
a molecular level. Adeno-associated virus (AAV) has been of increasing interest as a gene …