Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …

Skin color diversity is the most variable and noticeable phenotypic trait in humans resulting
from constitutive pigmentation variability. This paper will review the characterization of skin …

We conduct high coverage (> 30×) whole-genome sequencing of 180 individuals from 12
indigenous African populations. We identify millions of unreported variants, many predicted …

Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted
by genetics, UV exposure, and some drugs. Patients' physical appearance, psychological …

Abstract Forensic DNA Phenotyping (FDP), ie the prediction of human externally visible traits
from DNA, has become a fast growing subfield within forensic genetics due to the …

Skin color, one of the most diverse human traits, is determined by the quantity, type, and
distribution of melanin. In this study, we leveraged the light-scattering properties of melanin …

Background Information about global and local epidemiology and trends of skin cancers is
limited, which increases the difficulty of cutaneous cancer control. Methods To estimate the …

The deterioration of the skin morphology and physiology is the first and earliest obvious
harbinger of the aging process which is progressively manifested with increasing age. Such …

Skin color is highly variable in Africans, yet little is known about the underlying molecular
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …

We report a genome-wide association scan in> 6,000 Latin Americans for pigmentation of
skin and eyes. We found eighteen signals of association at twelve genomic regions. These …