Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths
annually despite the availability of several multivalent pneumococcal conjugate vaccines …

Human zinc deficiency increases susceptibility to bacterial infection. Although zinc
supplementation therapies can reduce the impact of disease, the molecular basis for …

Streptococcus sanguinis is a primary colonizer of teeth and is typically considered beneficial
due to its antagonistic relationship with the cariogenic pathogen Streptococcus mutans …

Streptococcus suis is an recognized zoonotic pathogen of swine and severely threatens
human health. Zinc is the second most abundant transition metal in biological systems …

Transition metals are nutrients essential for life. However, an excess of metals can be toxic
to cells, and host-imposed metal toxicity is an important mechanism for controlling bacterial …

Zinc homeostasis is critical for bacterial survival and is mediated largely at the transcriptional
level by the regulation of zinc uptake and efflux genes. Here we use RNA-seq to assess …

Streptococcus pneumoniae colonizes the human nasopharyngeal mucosa and is a leading
cause of community-acquired pneumonia, acute otitis media, and bacterial meningitis. Metal …

Most living organisms require zinc for survival; however, excessive amounts of this trace
element can be toxic. Therefore, the frequent fluctuations of salivary zinc, caused by the low …

Zinc (II) ions play critical roles in all known life as structurally important stabilizing ions in
proteins, catalytically active metals in enzymes, and signaling agents impacting …

The pathology associated with human respiratory tract bacterial agents that exist as
opportunistic commensals in the nasopharynx cause infections. This is particularly true for …