High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Peroxiredoxin 1–an antioxidant enzyme in cancer

C Ding, X Fan, G Wu - Journal of cellular and molecular …, 2017 - Wiley Online Library
Peroxiredoxins (PRDX s), a ubiquitous family of redox‐regulating proteins, are reported of
potential to eliminate various reactive oxygen species (ROS). As a major member of the …

Ascorbic acid and its pro-oxidant activity as a therapy for tumours of oral cavity–A systematic review

MC Putchala, P Ramani, HJ Sherlin, P Premkumar… - Archives of oral …, 2013 - Elsevier
BACKGROUND: Ascorbic acid or Vitamin C is a potent dietary antioxidant with a double
faced character, in that it exhibits a pro-oxidant activity arising from its routine antioxidant …

[HTML][HTML] Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

M Lee, JL Hirpara, JQ Eu, G Sethi, L Wang, BC Goh… - Redox biology, 2019 - Elsevier
Drug resistance invariably limits the response of oncogene-addicted cancer cells to targeted
therapy. The upregulation of signal transducer and activator of transcription 3 (STAT3) has …

Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways

S Mukherjee, S Ghosh, S Choudhury… - The Journal of nutritional …, 2013 - Elsevier
The clinical efficacy of the widely used chemotherapeutic drug methotrexate (MTX) is limited
due to its associated hepatotoxicity. Pomegranate polyphenols are of huge health benefits …

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect

D Ivanova, Z Zhelev, P Getsov, B Nikolova, I Aoki… - Redox biology, 2018 - Elsevier
This review is directed to the redox-modulating properties and anticancer effect of vitamin K.
The concept is focused on two aspects:(i) redox-cycle of vitamin K and its effect on the …

Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway

Y Wang, N Li, Z Zeng, L Tang, S Zhao… - Molecular Human …, 2021 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among
women of reproductive age, whereas the pathogenesis is still not fully understood. Systemic …

Vitamin K contribution to DNA damage—advantage or disadvantage? A Human Health Response

J Kaźmierczak-Barańska, BT Karwowski - Nutrients, 2022 - mdpi.com
Vitamin K is the common name for a group of compounds recognized as essential for blood
clotting. The group comprises phylloquinone (K1)—a 2-methyl-3-phytyl-1, 4 …

The role of pyruvate kinase M2 in anticancer therapeutic treatments

Q Su, S Luo, Q Tan, J Deng, S Zhou… - Oncology …, 2019 - spandidos-publications.com
Cancer cells are characterized by a high glycolytic rate, which leads to energy regeneration
and anabolic metabolism; a consequence of this is the abnormal expression of pyruvate …

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 regulators that affect expression and enzymatic activity

HVT Vo, YT Nguyen, N Kim, HJ Lee - International journal of molecular …, 2023 - mdpi.com
Fat-soluble vitamins (vitamin A, D, E, and K) assume a pivotal role in maintaining human
homeostasis by virtue of their enzymatic functions. The daily inclusion of these vitamins is …