Mechanisms of B-cell oncogenesis induced by Epstein-Barr virus
A Saha, ES Robertson - Journal of Virology, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects
the majority of the world population. Under immunocompromised conditions, EBV can …
the majority of the world population. Under immunocompromised conditions, EBV can …
The cooperative functions of the EBNA3 proteins are central to EBV persistence and latency
CT Styles, K Paschos, RE White, PJ Farrell - Pathogens, 2018 - mdpi.com
The Epstein–Barr nuclear antigen 3 (EBNA3) family of proteins, comprising EBNA3A,
EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long …
EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long …
The Epstein-Barr virus regulome in lymphoblastoid cells
Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell
lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV …
lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV …
MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs
CD Wood, H Veenstra, S Khasnis, A Gunnell… - Elife, 2016 - elifesciences.org
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-
driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim) …
driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim) …
Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro
Human B cells encompass functionally diverse lineages and phenotypic states that
contribute to protective as well as pathogenic responses. Epstein-Barr virus (EBV) provides …
contribute to protective as well as pathogenic responses. Epstein-Barr virus (EBV) provides …
Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells
JS Kalchschmidt, R Bashford-Rogers… - Journal of Experimental …, 2016 - rupress.org
Activation-induced cytidine deaminase (AID), the enzyme responsible for induction of
sequence variation in immunoglobulins (Igs) during the process of somatic hypermutation …
sequence variation in immunoglobulins (Igs) during the process of somatic hypermutation …
EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency
CT Styles, Q Bazot, GA Parker, RE White… - PLoS …, 2017 - journals.plos.org
Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and
proliferate. If the cells are infected ex vivo, they are transformed into continuously …
proliferate. If the cells are infected ex vivo, they are transformed into continuously …
Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors
Cooperativity and antagonism between transcription factors (TFs) can drastically modify their
binding to regulatory DNA elements. While mapping these relationships between TFs is …
binding to regulatory DNA elements. While mapping these relationships between TFs is …
Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival
Epstein-Barr virus (EBV) oncoprotein EBNA3C is indispensable for primary B-cell
transformation and maintenance of lymphoblastoid cells outgrowth. EBNA3C usurps two …
transformation and maintenance of lymphoblastoid cells outgrowth. EBNA3C usurps two …
EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells
LV Glaser, S Rieger, S Thumann, S Beer… - PLoS …, 2017 - journals.plos.org
Epstein-Barr virus (EBV) infection converts resting human B cells into permanently
proliferating lymphoblastoid cell lines (LCLs). The Epstein-Barr virus nuclear antigen 2 …
proliferating lymphoblastoid cell lines (LCLs). The Epstein-Barr virus nuclear antigen 2 …