Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules

BF Cress, JA Englaender, W He… - FEMS microbiology …, 2014 - academic.oup.com
The increasing prevalence of antibiotic-resistant bacteria portends an impending
postantibiotic age, characterized by diminishing efficacy of common antibiotics and routine …

Enterobacterial common antigen: synthesis and function of an enigmatic molecule

AK Rai, AM Mitchell - MBio, 2020 - Am Soc Microbiol
The outer membrane (OM) of Gram-negative bacteria poses a barrier to antibiotic entry due
to its high impermeability. Thus, there is an urgent need to study the function and biogenesis …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010

DJ Harvey - Mass spectrometry reviews, 2015 - Wiley Online Library
This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

Modeling and simulation of bacterial outer membranes with lipopolysaccharides and enterobacterial common antigen

Y Gao, J Lee, G Widmalm, W Im - The Journal of Physical …, 2020 - ACS Publications
Enterobacterial common antigen (ECA) is a surface glycolipid shared by all members of the
Enterobacteriaceae family. In addition to lipopolysaccharides (LPS), ECA is an important …

GRASS: semi-automated NMR-based structure elucidation of saccharides

RR Kapaev, PV Toukach - Bioinformatics, 2018 - academic.oup.com
Motivation Carbohydrates play crucial roles in various biochemical processes and are useful
for developing drugs and vaccines. However, in case of carbohydrates, the primary structure …

First evidence for a covalent linkage between enterobacterial common antigen and lipopolysaccharide in Shigella sonnei phase II ECALPS

TK Gozdziewicz, C Lugowski, J Lukasiewicz - Journal of Biological …, 2014 - ASBMB
Enterobacterial common antigen (ECA) is expressed by Gram-negative bacteria belonging
to Enterobacteriaceae, including emerging drug-resistant pathogens such as Escherichia …

A New Look at the Enterobacterial Common Antigen Forms Obtained during Rough Lipopolysaccharides Purification

TK Gozdziewicz, A Maciejewska, A Tsybulska… - International Journal of …, 2021 - mdpi.com
Enterobacterial common antigen (ECA) is a conserved antigen expressed by enterobacteria.
It is built by trisaccharide repeating units:→ 3)-α-D-Fuc p 4NAc-(1→ 4)-β-D-Man p NAcA …

The structure and significance of enterobacterial common antigen (ECA)

TK Goździewicz, J Łukasiewicz… - Postepy Higieny I …, 2015 - europepmc.org
The enterobacterial common antigen (ECA) is a carbohydrate-derived cell surface antigen
present in all Gram-negative bacteria belonging to Enterobacteriaceae family. Biosynthetic …

Structural studies of the O-antigen polysaccharide from Escherichia coli O115 and biosynthetic aspects thereof

C Fontana, K Ramström, A Weintraub… - …, 2013 - academic.oup.com
The structure of the O-antigen polysaccharide (PS) of Escherichia coli O115 has been
investigated using a combination of component analysis and 1D and 2D nuclear magnetic …