Purpose 'Big data'are accumulating in a multitude of domains and offer novel opportunities
for research. The role of these resources in mental health investigations remains relatively …

Long-term benzodiazepines (BZDs) use is not endorsed in the treatment guidelines for
anxiety disorders, but is prevalent in the real-world clinical settings. A systematic literature …

Abstract Purpose Base de Datos para la Investigación Farmacoepidemiológica en Atención
Primaria (BIFAP) is a population based database administered by the AEMPS (Spanish …

Objectives To evaluate the risk of all cause mortality associated with initiating compared with
not initiating benzodiazepines in adults, and to address potential treatment barriers and …

Background: Benzodiazepine treatment recommendations for older adults differ markedly
between guidelines, especially their advice on the acceptability of long-term use. Aims …

Objective To test the hypothesis that the use of chondroitin sulfate (CS) or glucosamine
reduces the risk of acute myocardial infarction (AMI). Design Case-control study nested in a …

Background There is controversy surrounding the risk of ischemic stroke associated with the
use of calcium supplements either in monotherapy or in combination with vitamin D …

Purpose To assess the impact of a variety of methodological parameters on the association
between six drug classes and five key adverse events in multiple databases. Methods The …

Background Contrary to most European guidelines, benzodiazepine receptor agonists
(BZRA) are often used continuously at a low dosage, being the most common form of long …

A wide range of analytic and data sharing options are available in nonexperimental
multidatabase studies designed to assess the real‐world benefits and risks of medical …