[HTML][HTML] AI-based monitoring of retinal fluid in disease activity and under therapy

U Schmidt-Erfurth, GS Reiter, S Riedl… - Progress in retinal and …, 2022 - Elsevier
Retinal fluid as the major biomarker in exudative macular disease is accurately visualized by
high-resolution three-dimensional optical coherence tomography (OCT), which is used …

[PDF][PDF] Progress and challenges of anti-VEGF agents and their sustained-release strategies for retinal angiogenesis

M Xu, R Fan, X Fan, Y Shao, X Li - Drug design, development and …, 2023 - Taylor & Francis
Currently, the treatment for ocular neovascular diseases, including diabetic macular edema
(DME) and age-related macular degeneration (AMD), mainly involves repeated intravitreal …

Evolving treatment paradigms for PCV

BJ Fenner, CMG Cheung, SS Sim, WK Lee… - Eye, 2022 - nature.com
Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular AMD (nAMD) that
accounts for a significant proportion of nAMD cases worldwide, and particularly in Asia …

METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial–mesenchymal transition

Y Wang, Y Chen, J Liang, M Jiang… - Journal of Molecular …, 2023 - academic.oup.com
Subretinal fibrosis is a major cause of the poor visual prognosis for patients with
neovascular age-related macular degeneration (nAMD). Myofibroblasts originated from …

Importance of treatment duration: unmasking barriers and discovering the reasons for undertreatment of anti-VEGF agents in neovascular age-related macular …

B Sobolewska, M Sabsabi, F Ziemssen - Clinical Ophthalmology, 2021 - Taylor & Francis
Purpose Since non-adherence (NA) to intravitreal therapy with VEGF drugs is one of the
most important modifiable factors compromising treatment outcome of nAMD, the purpose of …

[HTML][HTML] Ten-year incidence of fibrosis and risk factors for its development in neovascular age-related macular degeneration

F Romano, E Cozzi, M Airaldi, M Nassisi, F Viola… - American Journal of …, 2023 - Elsevier
PURPOSE To report the incidence and risk factors for fibrosis at 10 years in a large cohort of
persons with neovascular age-related macular degeneration (nAMD). DESIGN …

Review of fibrosis in neovascular age-related macular degeneration

KX Cheong, CMG Cheung, KYC Teo - American journal of ophthalmology, 2023 - Elsevier
Purpose To report the diagnosis and definitions, epidemiology, risk factors, and visual
outcomes of fibrosis in neovascular age-related macular degeneration (nAMD). Design …

Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods

CA Curcio, G McGwin, SR Sadda, Z Hu, ME Clark… - BMC …, 2020 - Springer
Background Age-related macular degeneration (AMD), a leading cause of irreversible vision
impairment in the United States and globally, is a disease of the photoreceptor support …

Lesion area progression in eyes with neovascular age-related macular degeneration treated using a proactive or a reactive regimen

M Cozzi, D Monteduro, RA Esposito, KL Spooner… - Eye, 2024 - nature.com
Background To compare the change in lesion area over 4 years of follow-up in eyes with
neovascular age-related macular degeneration (nAMD) treated with anti-vascular …

Predictors of visual acuity after treatment of neovascular age-related macular degeneration–current perspectives

LT Phan, GK Broadhead, TH Hong… - Clinical …, 2021 - Taylor & Francis
Visual acuity is a key outcome measure in the treatment of neovascular age-related macular
degeneration (nAMD) using anti-vascular endothelial growth factor agents. Large variations …