Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Imbalances between excitation and inhibition in synaptic transmission and neural circuits
have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Since aberrant miRNA expression has been implicated in numerous brain diseases, we
studied miRNA expression and miRNA regulation of important signaling pathways during …

Alzheimer's disease (AD) is associated with an elevated risk for seizures that may be
fundamentally connected to cognitive dysfunction. Supporting this link, many mouse models …

Key points In focal epilepsy the propagation of seizure discharges arising at restricted brain
sites is opposed by feedforward inhibition. Failure of this inhibition marks focal seizure …

Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …

Summary Neuregulin 1 (Nrg1) is a susceptibility gene of schizophrenia, a disabling mental
illness that affects 1% of the general population. Here, we show that ctoNrg1 mice, which …

GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV
INs) are important regulators of cortical network excitability and of gamma oscillations …