First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics
Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …
Pharmacophore modeling: advances, limitations, and current utility in drug discovery
X Qing, X Yin Lee, J De Raeymaeker… - Journal of Receptor …, 2014 - Taylor & Francis
Pharmacophore modeling is a successful yet very diverse subfield of computer-aided drug
design. The concept of the pharmacophore has been widely applied to the rational design of …
design. The concept of the pharmacophore has been widely applied to the rational design of …
In vitro–in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises
JO Miners, KM Knights, JB Houston… - Biochemical …, 2006 - Elsevier
Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily are responsible for the
metabolism of many drugs, environmental chemicals and endogenous compounds …
metabolism of many drugs, environmental chemicals and endogenous compounds …
Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches
Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT), which both exist as
enzyme “superfamilies,” are together responsible for the metabolism of most hepatically …
enzyme “superfamilies,” are together responsible for the metabolism of most hepatically …
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping
Enzymes of the UDP-glucuronosyltransferase (UGT) superfamily contribute to the
elimination of drugs from almost all therapeutic classes. Awareness of the importance of …
elimination of drugs from almost all therapeutic classes. Awareness of the importance of …
Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation
V Uchaipichat, LK Winner, PI Mackenzie… - British journal of …, 2006 - Wiley Online Library
Aims Using the fluconazole–zidovudine (AZT) interaction as a model, to determine whether
inhibition of UDP–glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could …
inhibition of UDP–glucuronosyltransferase (UGT) catalysed drug metabolism in vivo could …
In silico ADME prediction: data, models, facts and myths
F Lombardo, E Gifford… - Mini reviews in medicinal …, 2003 - ingentaconnect.com
A critical review of a very recent work in the field of in silico ADME prediction is presented
with emphasis on the work published during the period 2000-2002, and several other review …
with emphasis on the work published during the period 2000-2002, and several other review …
[引用][C] Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and …
V Uchaipichat, PI Mackenzie, XH Guo… - Drug Metabolism and …, 2004 - ASPET
[引用][C] Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and …
V Uchaipichat, PI Mackenzie, DJ Elliot… - Drug metabolism and …, 2006 - ASPET
[引用][C] In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction
A Rowland, DJ Elliot, JA Williams, PI Mackenzie… - Drug Metabolism and …, 2006 - ASPET