Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

The complexity of intracellular signalling requires both a diversity of molecular players and
the sequestration of activity to unique compartments within the cell. Recent findings on the …

Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have
been associated with defects in the organization of endothelial cell junctions. Understanding …

The epithelial–mesenchymal transition is essential in both embryonic development and the
progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been …

WNT proteins are secreted morphogens that are required for basic developmental
processes, such as cell-fate specification, progenitor-cell proliferation and the control of …

Objective Endophenotype studies of obsessive-compulsive disorder (OCD) may uncover
heritable traits that are related to genetic susceptibility to OCD. Deficient response inhibition …

Wnt/β-catenin signaling is a branch of a functional network that dates back to the first
metazoans and it is involved in a broad range of biological systems including stem cells …

Armadillo (ARM)-repeat proteins form a large family with diverse and fundamental functions
in many eukaryotes. ARM-repeat proteins have largely been characterised in multicellular …

Abstract p120 catenin is the best studied member of a subfamily of proteins that associate
with the cadherin juxtamembrane domain to suppress cadherin endocytosis. p120 also …