BCAA metabolism and insulin sensitivity–Dysregulated by metabolic status?

NP Gannon, JK Schnuck… - Molecular nutrition & food …, 2018 - Wiley Online Library
Branched‐chain amino acids (BCAAs) appear to influence several synthetic and catabolic
cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most …

Amino acids in the nutrition and production of sheep and goats

Y Cao, J Yao, X Sun, S Liu, GB Martin - … and Health: Amino Acids in the …, 2021 - Springer
In sheep and goats, amino acid nutrition is essential for the maintenance of health and
productivity. In this review, we analysed literature, mostly from the past two decades …

Branched‐Chain Amino Acids and Mitochondrial Biogenesis: An Overview and Mechanistic Summary

JS Hinkle, CN Rivera… - Molecular Nutrition & Food …, 2022 - Wiley Online Library
Branched‐chain amino acids (BCAA) are essential in the diet and promote several vital cell
responses which may have benefits for health and athletic performance, as well as disease …

Amino acid transporters in the regulation of insulin secretion and signalling

K Javed, SJ Fairweather - Biochemical Society Transactions, 2019 - portlandpress.com
Amino acids are increasingly recognised as modulators of nutrient disposal, including their
role in regulating blood glucose through interactions with insulin signalling. More recently …

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men

WK Mitchell, BE Phillips, I Hill, P Greenhaff… - Clinical …, 2017 - portlandpress.com
Leucine modulates muscle protein synthesis (MPS), with potential to facilitate
accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly …

[HTML][HTML] BCAA dysmetabolism in the host and gut microbiome, a key player in the development of obesity and T2DM

N Li, Z Cen, Z Zhao, Z Li, S Chen - Medicine in Microecology, 2023 - Elsevier
Branched chain amino acids (BCAAs) are essential amino acids required by mammals.
Recently, accumulating evidence has revealed the important connection between the …

Synergistic effect of increased total protein intake and strength training on muscle strength: a dose-response meta-analysis of randomized controlled trials

R Tagawa, D Watanabe, K Ito, T Otsuyama… - Sports Medicine …, 2022 - Springer
Background Protein supplementation augments muscle strength gain during resistance
training. Although some studies focus on the dose-response relationship of total protein …

Leucine supplementation differently modulates branched-chain amino acid catabolism, mitochondrial function and metabolic profiles at the different stage of insulin …

R Liu, H Li, W Fan, Q Jin, T Chao, Y Wu, J Huang… - Nutrients, 2017 - mdpi.com
The available findings concerning the association between branched-chain amino acids
(BCAAs)—particularly leucine—and insulin resistance are conflicting. BCAAs have been …

Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis and oxidative metabolism with enhanced GLUT4 content and glucose uptake in myotubes

JK Schnuck, KL Sunderland, NP Gannon, MR Kuennen… - Biochimie, 2016 - Elsevier
Leucine stimulates anabolic and catabolic processes in skeletal muscle, however little is
known about the effects of leucine on peroxisome proliferator-activated receptor (PPAR) …

Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling

A Morio, R Tsutsumi, T Kondo, H Miyoshi, T Kato… - Nutrition, Metabolism …, 2021 - Elsevier
Background and aims Coronary heart disease is a major global health concern. Further,
severity of this condition is greatly influenced by myocardial ischemia/reperfusion (I/R) injury …