Making ammonia from nitrogen and water microdroplets

X Song, C Basheer, RN Zare - Proceedings of the National …, 2023 - National Acad Sciences
Water (H2O) microdroplets are sprayed onto a magnetic iron oxide (Fe3O4) and Nafion-
coated graphite mesh using compressed N2 or air as the nebulizing gas. The resulting …

Direct C(sp3)–N Bond Formation between Toluene and Amine in Water Microdroplets

Y Meng, E Gnanamani, RN Zare - Journal of the American …, 2022 - ACS Publications
Unlike the inertness of bulk water, water microdroplets exhibit some remarkable reactivities.
We report that water microdroplets can directly produce stable C7H7+ cations (a …

Spontaneous Generation of Aryl Carbocations from Phenols in Aqueous Microdroplets: Aromatic SN1 Reactions at the Air–Water Interface

A Nandy, A Kumar, S Mondal, D Koner… - Journal of the …, 2023 - ACS Publications
Although phenol is stable in bulk water, we report an exceptional phenomenon in which
phenol is spontaneously transformed into a phenyl carbocation (Ph+) in water microdroplets …

One-step formation of pharmaceuticals having a phenylacetic acid core using water microdroplets

Y Meng, E Gnanamani, RN Zare - Journal of the American …, 2023 - ACS Publications
The properties of water microdroplets strikingly differ from bulk water. Using room-
temperature water microdroplets, we find that toluene can react with CO2 to form …

Heavy water microdroplet surface enriches the lighter isotopologue impurities

A Nandy, S Mondal, D Koner… - Journal of the American …, 2024 - ACS Publications
Water microdroplets promote unusual chemical reactions at the air–water interface.
However, the interfacial structure of water microdroplets and its potential influence on …

Destabilized Carbocations Caged in Water Microdroplets: Isolation and Real-Time Detection of α-Carbonyl Cation Intermediates

A Kumar, S Mondal, Sandeep… - Journal of the …, 2022 - ACS Publications
Over the last 50 years, proposals of α-carbonyl cation intermediates have been driven by
chemical intuition and indirect evidence. Recently, wide interest in α-carbonyl cation …

Capturing reactive carbanions by microdroplets

A Kumar, S Mondal, M Mofidfar, RN Zare… - Journal of the …, 2022 - ACS Publications
Carbanions appear in many organic or biological reactions as fleeting intermediates,
prohibiting direct observation or spectroscopic measurement. An aqueous environment is …

Revisiting the Enhanced Chemical Reactivity in Water Microdroplets: The Case of a Diels–Alder Reaction

K Gong, A Nandy, Z Song, QS Li… - Journal of the …, 2024 - ACS Publications
Often, chemical reactions are markedly accelerated in microdroplets compared with the
corresponding bulk phase. While identifying the precise causative factors remains …

Water Microdroplet Chemistry for Accelerating Green Thiocyanation and Discovering Water-Controlled Divergence

L Xue, B Zheng, J Sun, J Liu… - … Sustainable Chemistry & …, 2023 - ACS Publications
As an important class of five-membered N-heterocyclic compounds, pyrazolin-5-one
derivatives play an extremely important role in the construction of fine chemicals and …

Microdroplet Chemistry Accelerating a Three-Component Passerini Reaction for α-Acyloxy Carboxamide Synthesis

Y Wu, H Cheng, J Li, J Liu, J Sun - The Journal of Organic …, 2023 - ACS Publications
α-Acyloxy carboxamides are important multifunctional natural products that show bioactive
and pharmacological activities. Traditional three-component Passerini reactions among …