Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders

CA Turner, E Eren-Koçak, EG Inui, SJ Watson… - Seminars in cell & …, 2016 - Elsevier
The role of the fibroblast growth factor (FGF) system in brain-related disorders has received
considerable attention in recent years. To understand the role of this system in neurological …

Fibroblast growth factor signaling in the developing neuroendocrine hypothalamus

PS Tsai, LR Brooks, JR Rochester… - Frontiers in …, 2011 - Elsevier
Fibroblast growth factor (FGF) signaling is pivotal to the formation of numerous central
regions. Increasing evidence suggests FGF signaling also directs the development of the …

Fibroblast growth factor 8b (FGF-8b) enhances myogenesis and inhibits adipogenesis in rotator cuff muscle cell populations in vitro

T Otsuka, HM Kan, PY Mengsteab… - Proceedings of the …, 2024 - National Acad Sciences
Fatty expansion is one of the features of muscle degeneration due to muscle injuries, and its
presence interferes with muscle regeneration. Specifically, poor clinical outcomes have …

[HTML][HTML] miR-6742-5p regulates the invasion and migration of lung adenocarcinoma cells via mediating FGF8/ERK12/MMP9/MMP2 signaling pathway

M Song, X Xing - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Background: microRNAs (miRNAs) are involved in the progression of Lung adenocarcinoma
(LUAD), however, the functions of miR-6742-5p in LUAD remains unknown, thereby this …

Physiological characterization and transcriptomic properties of GnRH neurons derived from human stem cells

KL Keen, AJ Petersen, AG Figueroa, BI Fordyce… - …, 2021 - academic.oup.com
Gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus play a key role in
the regulation of reproductive function. In this study, we sought an efficient method for …

Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells

C Lund, V Yellapragada, S Vuoristo… - Disease models & …, 2020 - journals.biologists.com
Gonadotropin-releasing hormone (GnRH) neurons provide a fundamental signal for the
onset of puberty and subsequent reproductive functions by secretion of gonadotropin …

FGF8–FGFR1 signaling regulates human GnRH neuron differentiation in a time-and dose-dependent manner

V Yellapragada, N Eskici, Y Wang… - Disease Models & …, 2022 - journals.biologists.com
ABSTRACT Fibroblast growth factor 8 (FGF8), acting through the fibroblast growth factor
receptor 1 (FGFR1), has an important role in the development of gonadotropin-releasing …

Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer

R Graumann, GA Di Capua, JE Oyarzún, MA Vásquez… - PloS one, 2017 - journals.plos.org
Teneurins are a family of highly conserved pair-rule proteins involved in morphogenesis and
development of the central nervous system. Their function in adult tissues and in disease is …

Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth

KM Tarkkonen, EM Nilsson, TE Kähkönen, JH Dey… - PLoS …, 2012 - journals.plos.org
Fibroblast growth factors (FGFs) regulate the growth and progression of breast cancer. FGF
signaling is transduced through FGF receptors 1–4, which have oncogenic or anti …

Nucleolin loss of function leads to aberrant Fibroblast Growth Factor signaling and craniofacial anomalies

S Dash, PA Trainor - Development, 2022 - journals.biologists.com
Ribosomal RNA (rRNA) transcription and ribosome biogenesis are global processes
required for growth and proliferation of all cells, yet perturbation of these processes in …