Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …

Heart failure is a serious global health challenge, affecting more than 6.2 million people in
the United States and is projected to reach over 8 million by 2030. Independent of etiology …

Mitochondria are characterized by a high capacity to accumulate calcium thanks to the
electrochemical gradient created by the extrusion of protons in the respiratory chain …

Inter-organelle contacts are emerging as crucial hubs in cell signaling. Among these, the
long known ER-mitochondria tethers can be considered a reference model for these …

Parvalbumin (PV) is a cytosolic Ca 2+-binding protein highly expressed in fast skeletal
muscle, contributing to an increased relaxation rate. Moreover, PV is an" atrogene" …

The ability for skeletal muscle to perform optimally can be affected by the regulation of Ca 2+
within the triadic junctional space at rest. Reactive oxygen species impact muscle …

Calsequestrin 1 (CASQ1) and Ryanodine receptor 1 (RYR1) are two of the main players in
excitation–contraction (EC) coupling. CASQ1-knockout mice and mice carrying a mutation in …

The physical connection between mitochondria and endoplasmic reticulum (ER) is an
essential signaling hub to ensure organelle and cellular functions. In skeletal muscle, ER …

Background Radiotherapy is commonly used to treat childhood cancers and can have
adverse effects on muscle function, but the underlying mechanisms have yet to be fully …

The overall scientific goal of the workshop was to provide a forum that united leading
international RYR1 disease experts (researchers, clinicians, and geneticists) with affected …