Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors
Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …
metalloenzymes and they classically play a role in pH homeostasis maintenance. CA …
Recent advancements in the development of bioactive pyrazoline derivatives
Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …
been proven as a ubiquitous motif which is present in a number of pharmacologically …
[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds–determination of their carbonic anhydrase, acetylcholinesterase …
Abstract Sulfur-containing pyrroles (1–3), tris (2-pyridyl) phosphine (selenide) sulfide (4–5)
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …
Recent advances on biologically active coumarin-based hybrid compounds
Coumarin hybrids have been designed and synthesized as an important new strategy in the
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …
Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes
C Türkeş, Y Demir, Ş Beydemir - Journal of Biomolecular Structure …, 2021 - Taylor & Francis
Carbonic anhydrases (CAs) are potent dehydration of carbonic acid and catalyst of the
reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human …
reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human …
Synthesis and antioxidant activities of phenol derivatives from 1, 6-bis (dimethoxyphenyl) hexane-1, 6-dione
Abstract Starting from the compound (3, 4-dimethoxyphenyl)(2-(3, 4-dimethoxyphenyl)
cyclopent-1-en-1-yl) methanone (4), two diols and three tetrol derivatives were synthesised …
cyclopent-1-en-1-yl) methanone (4), two diols and three tetrol derivatives were synthesised …