The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

Recent studies have revealed that the TAM receptor protein tyrosine kinases—TYRO3, AXL
and MER—have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells …

Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness or
severe visual impairment before the age of 1 year. Linkage analysis, homozygosity mapping …

Removal of apoptotic cells is essential for maintenance of tissue homeostasis,
organogenesis, remodeling, development, and maintenance of the immune system …

Tyro‐3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs)
characterized by a conserved sequence within the kinase domain and adhesion molecule …

Purpose The RPE cell line ARPE-19 provides a dependable and widely used alternative to
native RPE. However, replication of the native RPE phenotype becomes more difficult …

Daily phagocytosis by the retinal pigment epithelium (RPE) of spent photoreceptor outer
segment fragments is critical for vision. In the retina, early morning circadian photoreceptor …

The Tyro3, Axl, and Mer (TAM) receptor tyrosine kinases and their ligands Gas6 and Protein
S are required for the optimal phagocytosis of apoptotic cells in the mature immune …