Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects
J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
Computational Investigation of Coaggregation and Cross-Seeding between Aβ and hIAPP Underpinning the Cross-Talk in Alzheimer's Disease and Type 2 Diabetes
The coexistence of amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP) in the brain
and pancreas is associated with an increased risk of Alzheimer's disease (AD) and type 2 …
and pancreas is associated with an increased risk of Alzheimer's disease (AD) and type 2 …
Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
Norepinephrine inhibits Alzheimer's amyloid-β peptide aggregation and destabilizes amyloid-β protofibrils: A molecular dynamics simulation study
The abnormal self-assembly of amyloid-β (Aβ) peptides into toxic fibrillar aggregates is
associated with the pathogenesis of Alzheimer's disease (AD). The inhibition of β-sheet-rich …
associated with the pathogenesis of Alzheimer's disease (AD). The inhibition of β-sheet-rich …
Near‐Infrared Switchable Fullerene‐Based Synergy Therapy for Alzheimer's Disease
C60 has a special dual function; it can act as both a powerful reactive oxygen species (ROS)
producer under UV or visible light and an ROS scavenger in the dark. However, ROS has …
producer under UV or visible light and an ROS scavenger in the dark. However, ROS has …
Computational insights into the cross-talk between medin and Aβ: implications for age-related vascular risk factors in Alzheimer's disease
The aggregation of medin forming aortic medial amyloid is linked to arterial wall
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
Computer simulations of intrinsically disordered proteins
The investigation of intrinsically disordered proteins (IDPs) is a new frontier in structural and
molecular biology that requires a new paradigm to connect structural disorder to function …
molecular biology that requires a new paradigm to connect structural disorder to function …
SEVI inhibits Aβ amyloid aggregation by capping the β-sheet elongation edges
Inhibiting the aggregation of amyloid peptides with endogenous peptides has broad interest
due to their intrinsically high biocompatibility and low immunogenicity. Here, we investigated …
due to their intrinsically high biocompatibility and low immunogenicity. Here, we investigated …
Mechanistic insight into the disruption of Tau R3–R4 protofibrils by curcumin and epinephrine: An all-atom molecular dynamics study
The accumulation of Tau protein aggregates is a pathological hallmark of tauopathy,
including chronic traumatic encephalopathy (CTE). Inhibiting Tau aggregation or disrupting …
including chronic traumatic encephalopathy (CTE). Inhibiting Tau aggregation or disrupting …