Cigarette smoking is the major cause of preventable death and morbidity throughout the
world. Many compounds are present in tobacco, but nicotine is the primary addictive one …

Nicotinic acetylcholine receptors are ligand‐gated ion channels that exogenously bind
nicotine. Nicotine produces rewarding effects by interacting with these receptors in the …

Background Smoking and alcohol use have been associated with common genetic variants
in multiple loci. Rare variants within these loci hold promise in the identification of biological …

Tobacco use leads to 6 million deaths every year due to severe long‐lasting diseases. The
main component of tobacco, nicotine, is recognized as one of the most addictive drugs …

Cigarette smoking is a leading cause of preventable death throughout the world. Nicotine,
the primary addictive compound in tobacco, plays a vital role in the initiation and …

It has been hypothesized that the nicotinic acetylcholine receptors (nAChRs) play important
roles in nicotine dependence (ND) and influence the number of cigarettes smoked per day …

Nicotine exerts its physiological and pharmacological roles in the brain through neuronal
nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels consisting …

Cigarette smoking continues to be a leading cause of preventable death. The rate of
nicotine's metabolic inactivation is mediated predominately by CYP2A6 enzyme activity …

Autism spectrum conditions are neurodevelopmental conditions that entail social-
communication difficulties, unusually narrow interests and difficulties adjusting to …

Background Smoking and alcohol use behaviors in humans have been associated with
common genetic variants within multiple genomic loci. Investigation of rare variation within …