Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis
Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
High-frequency brain activity and muscle artifacts in MEG/EEG: a review and recommendations
SD Muthukumaraswamy - Frontiers in human neuroscience, 2013 - frontiersin.org
In recent years high-frequency brain activity in the gamma-frequency band (30–80 Hz) and
above has become the focus of a growing body of work in MEG/EEG research …
above has become the focus of a growing body of work in MEG/EEG research …
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
Ketamine's mechanism of action was assessed using gamma power from
magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 …
magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 …
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
TH Pham, AM Gardier - Pharmacology & therapeutics, 2019 - Elsevier
Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms
S Kohtala - Pharmacological Reports, 2021 - Springer
Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …
medicine as an important anesthetic with many uses. More recently, ketamine has been …
Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics
Ketamine is the prototype for a new generation of glutamate-based antidepressants that
rapidly alleviate depression within hours of treatment. Over the past decade, there has been …
rapidly alleviate depression within hours of treatment. Over the past decade, there has been …
An excitatory synapse hypothesis of depression
Depression is a common cause of mortality and morbidity, but the biological bases of the
deficits in emotional and cognitive processing remain incompletely understood. Current …
deficits in emotional and cognitive processing remain incompletely understood. Current …
The use of ketamine as an antidepressant: a systematic review and meta‐analysis
CM Coyle, KR Laws - Human Psychopharmacology: Clinical …, 2015 - Wiley Online Library
Objective The current meta‐analysis examines the effects of ketamine infusion on
depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder …
depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder …