Tumor microenvironment: barrier or opportunity towards effective cancer therapy

A Tiwari, R Trivedi, SY Lin - Journal of biomedical science, 2022 - Springer
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

[HTML][HTML] Biomedical text mining and its applications in cancer research

F Zhu, P Patumcharoenpol, C Zhang, Y Yang… - Journal of biomedical …, 2013 - Elsevier
Cancer is a malignant disease that has caused millions of human deaths. Its study has a
long history of well over 100years. There have been an enormous number of publications on …

Differential oxidative status and immune characterization of the early and advanced stages of human breast cancer

C Panis, VJ Victorino, A Herrera, LF Freitas… - Breast cancer research …, 2012 - Springer
Breast cancer is the malignant neoplasia with the highest incidence in women worldwide.
Chronic oxidative stress and inflammation have been indicated as major mediators during …

CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early-and late-onset colorectal cancer

TH Ågesen, M Berg, T Clancy, E Thiis-Evensen… - Genes & …, 2011 - nature.com
Colorectal cancer (CRC) incidence increases with age, and early onset of the disease is an
indication of genetic predisposition, estimated to cause up to 30% of all cases. To identify …

Profiling networks of distinct immune-cells in tumors

T Clancy, E Hovig - BMC bioinformatics, 2016 - Springer
Background It is now clearly evident that cancer outcome and response to therapy is guided
by diverse immune-cell activity in tumors. Presently, a key challenge is to comprehensively …

A Nomogram Based on Circulating CD4+ T Lymphocytes and Lactate Dehydrogenase to Predict Distant Metastasis in Patients with Nasopharyngeal Carcinoma

D Shen, C Yan, K Chen, L Li, S Qu… - Journal of Inflammation …, 2021 - Taylor & Francis
Purpose Distant metastasis is the main pattern of treatment failure in nasopharyngeal
carcinoma (NPC) in the era of intensity-modulated radiotherapy (IMRT). We aimed to …

Growing trend of CE at the omics level: the frontier of systems biology–an update

E Ban, SH Park, MJ Kang, HJ Lee, EJ Song… - …, 2012 - Wiley Online Library
Omics is the study of proteins, peptides, genes, and metabolites in living organisms.
Systems biology aims to understand the system through the study of the relationship …

Personalized cancer immunotherapy using systems medicine approaches

SK Gupta, T Jaitly, U Schmitz, G Schuler… - Briefings in …, 2016 - academic.oup.com
The immune system is by definition multi-scale because it involves biochemical networks
that regulate cell fates across cell boundaries, but also because immune cells communicate …

Bioinformatics approaches to profile the tumor microenvironment for immunotherapeutic discovery

T Clancy, R Dannenfelser… - Current …, 2017 - ingentaconnect.com
In the microenvironment of a malignancy, tumor cells do not exist in isolation, but rather in a
diverse ecosystem consisting not only of heterogeneous tumor-cell clones, but also normal …

Quantifying the complexity of medical research

R Rodriguez-Esteban, WT Loging - Bioinformatics, 2013 - academic.oup.com
Motivation: A crucial phenomenon of our times is the diminishing marginal returns of
investments in pharmaceutical research and development. A potential reason is that …