Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications

X Fan, AR Sun, RSE Young, IO Afara, BR Hamilton… - Bone Research, 2024 - nature.com
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues,
including cartilage, bone, synovium, and adipose tissues. OA presents diverse clinical …

Therapeutics of the future: Navigating the pitfalls of extracellular vesicles research from an osteoarthritis perspective

A Karoichan, S Boucenna… - Journal of Extracellular …, 2024 - Wiley Online Library
Extracellular vesicles have gained wide momentum as potential therapeutics for
osteoarthritis, a highly prevalent chronic disease that still lacks an approved treatment. The …

Advances of mesenchymal stem cells released extracellular vesicles in periodontal bone remodeling

C Liu, Y Li, G Han - DNA and Cell Biology, 2022 - liebertpub.com
Extracellular vesicles (EVs) are nanoparticles that include exosomes, microvesicles, and
apoptotic bodies; they interact with target cell surface receptors and transport contents …

[HTML][HTML] Understanding molecular characteristics of extracellular vesicles derived from different types of mesenchymal stem cells for therapeutic translation

Z Ding, ZF Greenberg, MF Serafim, S Ali… - Extracellular …, 2024 - Elsevier
Mesenchymal stem cells (MSCs) have been studied for decades as candidates for cellular
therapy, and their secretome, including secreted extracellular vesicles (EVs), has been …

[HTML][HTML] Synovitis mediates the association between bone marrow lesions and knee pain in osteoarthritis: data from the Foundation for the National Institute of Health …

X Wang, T Chen, W Liang, T Fan, Z Zhu, P Cao… - Osteoarthritis and …, 2022 - Elsevier
Objectives Although subchondral bone marrow lesions (BMLs) and synovitis have been well
acknowledged as important sources of pain in knee osteoarthritis (KOA), it is unclear if …

[HTML][HTML] Extracellular vesicles are key players in mesenchymal stem cells' dual potential to regenerate and modulate the immune system

M van Griensven, ER Balmayor - Advanced Drug Delivery Reviews, 2024 - Elsevier
MSCs are used for treatment of inflammatory conditions or for regenerative purposes. MSCs
are complete cells and allogenic transplantation is in principle possible, but mostly …

Cross‐Tissue Analysis Using Machine Learning to Identify Novel Biomarkers for Knee Osteoarthritis

Y Zhao, Y Xia, G Kuang, J Cao… - … Methods in Medicine, 2022 - Wiley Online Library
Background. Knee osteoarthritis (KOA) is a common degenerative joint disease. In this
study, we aimed to identify new biomarkers of KOA to improve the accuracy of diagnosis and …

Functional and Molecular Analysis of Human Osteoarthritic Chondrocytes Treated with Bone Marrow-Derived MSC-EVs

A Scalzone, C Sanjurjo-Rodríguez… - Bioengineering, 2024 - mdpi.com
Osteoarthritis (OA) is a degenerative joint disease, causing impaired mobility. There are
currently no effective therapies other than palliative treatment. Mesenchymal stromal cells …

A call for standardization for secretome and extracellular vesicles in osteoarthritis: results show disease-modifying potential, but protocols are too heterogeneous—a …

D D'Arrigo, M Salerno, L De Marziani, A Boffa… - Human Cell, 2024 - Springer
The currently available osteoarthritis (OA) treatments offer symptoms' relief without disease-
modifying effects. Increasing evidence supports the role of human mesenchymal stem cells …

Mesenchymal stem cell‐derived exosomes and skin photoaging: From basic research to practical application

Y Wang, X Shen, S Song, Y Chen… - Photodermatology …, 2023 - Wiley Online Library
Background Skin photoaging is a condition caused by long‐term exposure to ultraviolet
irradiation, resulting in a variety of changes in the skin, such as capillary dilation, increased …