Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …

The complexity of glioblastoma multiforme, the most common and lethal variant of gliomas,
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …

Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …

Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …

Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant
subtypes based on core gene signatures. However, molecular signaling in glioma stem cells …

Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

Tissues with defined cellular hierarchies in development and homeostasis give rise to
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …

Heterogeneity is an omnipresent feature of mammalian cells in vitro and in vivo. It has been
recently realized that even mouse and human embryonic stem cells under the best culture …

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly
differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for …