The primary function of the skin is to act as a barrier against insults from the environment,
and its unique structure reflects this. The skin is composed of two layers: the epidermal outer …

Significance: Almost 7 million Americans have chronic cutaneous wounds and billions of
dollars are spent on their treatment. The number of patients with nonhealing wounds keeps …

Background Complex wounds impose a substantial health economic burden worldwide. As
wound care is managed across multiple settings by a range of healthcare professionals with …

Summary Guideline 1.1: Compression after thermal ablation or stripping of the saphenous
veins. When possible, we suggest compression (elastic stockings or wraps) should be used …

The skin wound microenvironment can be divided into two main components that influence
healing: the external wound microenvironment, which is outside the wound surface; and the …

Background The increasing numbers of surgeries involving high risk, multi-morbid patients,
coupled with inconsistencies in the practice of perioperative surgical wound care, increases …

Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves
as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a …

Chronic non-healing wounds are estimated to cost the US healthcare $28-$31 billion per
year. Diabetic ulcers, arterial and venous ulcers, and pressure ulcers are some of the most …

Background The possible impact of nutritional status on healing and course of disease in
patients with chronic wounds is widely suggested, however, most data are based on small …

Background Numerous, often multi-faceted regimens are available for treating complex
wounds, yet the evidence of these interventions is recondite across the literature. We aimed …