Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Dementia, and especially Alzheimer's disease (AD), puts significant burden on global
healthcare expenditure through its increasing prevalence. Research has convincingly …

Survival to extreme ages clusters within families. However, identifying genetic loci conferring
longevity and low morbidity in such longevous families is challenging. There is debate …

Globally, the lifespan of populations increases but the healthspan is lagging behind.
Previous research showed that survival into extreme ages (longevity) clusters in families as …

FOXO3 is a prominent longevity gene. To date, no-one has examined whether longevity-
associated FOXO3 genetic variants protect against mortality in all individuals, or only in …

Background: Successful aging is a prominent and worldwide theme in gerontology.
However, until recently, only few studies were conducted about successful aging in Iran …

Longevity is written into the genes. While many so-called “longevity genes” have been
identified, the reason why particular genetic variants are associated with longer lifespan has …

It is known that biological relatives of long-lived individuals demonstrate lower mortality and
longer life span compared to relatives of shorter-lived individuals, and at least part of this …

Introduction: Genetic variation in the phosphatidylinositol 3-kinase reregulatory subunit 1
gene (PIK3R1) is associated with longevity. Objective: The aim of the study was to determine …

Studies have shown that long-lived individuals seem to pass their survival advantage on to
their offspring. Offspring of long-lived parents had a lifelong survival advantage over …