Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

C Pifferi, R Fuentes, A Fernández-Tejada - Nature Reviews Chemistry, 2021 - nature.com
Modern subunit vaccines based on homogeneous antigens offer more precise targeting and
improved safety compared with traditional whole-pathogen vaccines. However, they are also …

Skin microbiota–host interactions

YE Chen, MA Fischbach, Y Belkaid - Nature, 2018 - nature.com
The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi
and viruses. These microbes—collectively referred to as the skin microbiota—are …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

The Innate Immune Response to Mycobacterium tuberculosis Infection

MM Ravesloot-Chávez, E Van Dis… - Annual review of …, 2021 - annualreviews.org
Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Macrophages in tuberculosis: friend or foe

E Guirado, LS Schlesinger, G Kaplan - Seminars in immunopathology, 2013 - Springer
Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b

MVS Rajaram, B Ni, JD Morris… - Proceedings of the …, 2011 - National Acad Sciences
Contact of Mycobacterium tuberculosis (M. tb) with the immune system requires interactions
between microbial surface molecules and host pattern recognition receptors. Major M. tb …

Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host–pathogen interaction

AK Mishra, NN Driessen, BJ Appelmelk… - FEMS microbiology …, 2011 - academic.oup.com
Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Molecular basis of mycobacterial survival in macrophages

JA Awuh, TH Flo - Cellular and Molecular Life Sciences, 2017 - Springer
Macrophages play an essential role in the immune system by ingesting and degrading
invading pathogens, initiating an inflammatory response and instructing adaptive immune …

RETRACTED: A Type I–Secreted, Sulfated Peptide Triggers XA21-Mediated Innate Immunity

SW Lee, SW Han, M Sririyanum, CJ Park, YS Seo… - Science, 2009 - science.org
The rice Xa21 gene confers immunity to most strains of the bacterium Xanthomonas oryzae
pv. oryzae (Xoo). Liquid chromatography–tandem mass spectrometry analysis of biologically …

Sensing of Mycobacterium tuberculosis and consequences to both host and bacillus

CE Stamm, AC Collins, MU Shiloh - Immunological reviews, 2015 - Wiley Online Library
Mycobacterium tuberculosis (Mtb), the primary causative agent of human tuberculosis, has
killed more people than any other bacterial pathogen in human history and remains one of …