Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome

CR Harrell, C Fellabaum, N Jovicic, V Djonov… - Cells, 2019 - mdpi.com
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …

[HTML][HTML] Ethical and safety issues of stem cell-based therapy

V Volarevic, BS Markovic, M Gazdic… - … journal of medical …, 2018 - ncbi.nlm.nih.gov
Results obtained from completed and on-going clinical studies indicate huge therapeutic
potential of stem cell-based therapy in the treatment of degenerative, autoimmune and …

[HTML][HTML] Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives

CR Harrell, BS Markovic, C Fellabaum… - Biomedicine & …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic, prevalent, debilitating joint disease characterized by
progressive cartilage degradation, subchondral bone remodeling, bone marrow lesions …

The current landscape of the mesenchymal stromal cell secretome: a new paradigm for cell-free regeneration

VBR Konala, MK Mamidi, R Bhonde, AK Das… - Cytotherapy, 2016 - Elsevier
The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their
multipotentiality have rendered them attractive to researchers and clinicians. In addition to …

Mesenchymal stem cells in tissue repair

AM DiMarino, AI Caplan, TL Bonfield - Frontiers in immunology, 2013 - frontiersin.org
The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has
been an exciting and new innovation for the treatment of a variety of diseases associated …

Mesenchymal stem cell-derived interleukin 1 receptor antagonist promotes macrophage polarization and inhibits B cell differentiation

P Luz-Crawford, F Djouad, K Toupet, C Bony… - Stem Cells, 2016 - academic.oup.com
The role of interleukin 1 receptor antagonist (IL1RA) in mediating the immunosuppressive
effect of mesenchymal stem/stromal cells (MSCs) has been reported in several studies …

Concise review: therapeutic potential of mesenchymal stem cells for the treatment of acute liver failure and cirrhosis

V Volarevic, J Nurkovic, N Arsenijevic, M Stojkovic - Stem cells, 2014 - academic.oup.com
Currently, the most effective therapy for acute liver failure and advanced cirrhosis is liver
transplantation. However, this procedure has several limitations, including lack of donors …

Mesenchymal stem cells: a friend or foe in immune-mediated diseases

M Gazdic, V Volarevic, N Arsenijevic… - Stem Cell Reviews and …, 2015 - Springer
Mesenchymal stem cells (MSCs) are adult, self-renewable, multipotent cells that can be
found in almost all postnatal tissues. Because of their capacity for self-renewal and …

Mesenchymal stem cell‐derived factors: Immuno‐modulatory effects and therapeutic potential

V Volarevic, M Gazdic, B Simovic Markovic… - Biofactors, 2017 - Wiley Online Library
Stem cell‐based therapy is considered to be a new hope in transplantation medicine.
Among stem cells, mesenchymal stem cells (MSCs) are, due to their differentiation and …

Mesenchymal stem cell-mediated effects of tumor support or suppression

KJ Rhee, JI Lee, YW Eom - International journal of molecular sciences, 2015 - mdpi.com
Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many
studies have reported that tumor progression and metastasis increase by MSCs. In contrast …