Physiology and pathophysiology in ultra-marathon running

B Knechtle, PT Nikolaidis - Frontiers in physiology, 2018 - frontiersin.org
In this overview, we summarize the findings of the literature with regards to physiology and
pathophysiology of ultra-marathon running. The number of ultra-marathon races and the …

Engineered skeletal muscles for disease modeling and drug discovery

J Wang, A Khodabukus, L Rao, K Vandusen… - Biomaterials, 2019 - Elsevier
Skeletal muscle is the largest organ of human body with several important roles in everyday
movement and metabolic homeostasis. The limited ability of small animal models of muscle …

Inflammatory cytokines in general and central obesity and modulating effects of physical activity

FM Schmidt, J Weschenfelder, C Sander, J Minkwitz… - PloS one, 2015 - journals.plos.org
Context Chronic systemic inflammation in obesity originates from local immune responses in
visceral adipose tissue. However, assessment of a broad range of inflammation-mediating …

[HTML][HTML] State of knowledge on molecular adaptations to exercise in humans: historical perspectives and future directions

KM Lavin, PM Coen, LC Baptista, MB Bell… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Effects of exercise training on intrahepatic lipid content in humans

B Brouwers, MKC Hesselink, P Schrauwen… - Diabetologia, 2016 - Springer
Non-alcoholic fatty liver (NAFL) is the most common liver disorder in western society.
Various factors may play a role in determining hepatic fat content, such as delivery of lipids …

Associations between dietary factors and markers of NAFLD in a general Dutch adult population

A Rietman, D Sluik, EJM Feskens, FJ Kok… - European journal of …, 2018 - nature.com
Results: In this population (mean age 53.0±11.4 years; BMI 25.9±4.0 kg/m 2; FLI 35.0±27.7),
the prevalence of fatty liver as indicated by an FLI> 60 was 21.5%. Subjects in the highest …

Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise

R Pillon Barcelos, LF Freire Royes… - Free radical …, 2017 - Taylor & Francis
The liver is remarkably important during exercise outcomes due to its contribution to
detoxification, synthesis, and release of biomolecules, and energy supply to the exercising …

Branched-chain amino acid supplementation in treatment of liver cirrhosis: Updated views on how to attenuate their harmful effects on cataplerosis and ammonia …

M Holeček - Nutrition, 2017 - Elsevier
Branched-chain amino acid (BCAA; valine, leucine, and isoleucine) supplementation is
common for patients with liver cirrhosis due to decreased levels of BCAA in the blood …

Effects of endurance and endurance–strength exercise on biochemical parameters of liver function in women with abdominal obesity

D Skrypnik, M Ratajczak, J Karolkiewicz… - Biomedicine & …, 2016 - Elsevier
Introduction Obesity is a risk factor of nonalcoholic fatty liver disease. Although the standard
therapy for obesity involves physical exercise, well-planned studies of the changes in liver …

Associations of aerobic fitness and maximal muscular strength with metabolites in young men

UM Kujala, JP Vaara, H Kainulainen… - JAMA Network …, 2019 - jamanetwork.com
Importance High physical fitness is associated with a reduction in risk of cardiovascular
diseases and death, but the underlying mechanisms are insufficiently understood. Objective …