The pervasive expression of circular RNAs (circRNAs) is a recently discovered feature of
gene expression in highly diverged eukaryotes. Numerous algorithms that are used to detect …

A transcriptome constructed from short-read RNA sequencing (RNA-seq) is an easily
attainable proxy catalog of protein-coding genes when genome assembly is unnecessary …

RNA-seq is currently considered the most powerful, robust and adaptable technique for
measuring gene expression and transcription activation at genome-wide level. As the …

METTL3 catalyzes the formation of N 6-methyl-adenosine (m 6 A) which has important roles
in regulating various biological processes. However, the in vivo function of Mettl3 remains …

RNA-Seq is a widely used method for studying the behavior of genes under different
biological conditions. An essential step in an RNA-Seq study is normalization, in which raw …

Housekeeping (HK) genes are constitutively expressed genes that are required for the
maintenance of basic cellular functions. Despite their importance in the calibration of gene …

Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

Quantile normalization is an important normalization technique commonly used in high-
dimensional data analysis. However, it is susceptible to class-effect proportion effects (the …

Background RNA sequencing technologies have allowed researchers to gain a better
understanding of how the transcriptome affects disease. However, sequencing technologies …

The recent development of cost‐effective high‐throughput DNA sequencing technologies
has tremendously increased microbiome research. However, it has been well documented …