Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
[HTML][HTML] Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression
G Schönrich, MJ Raftery, Y Samstag - Advances in biological regulation, 2020 - Elsevier
Abstract Pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge …
Platelet and megakaryocyte roles in innate and adaptive immunity
M Koupenova, AC Livada, CN Morrell - Circulation research, 2022 - Am Heart Assoc
Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …
hemostasis and thrombosis. This important platelet function has received significant …
[图书][B] Hematology E-Book: Basic Principles and Practice
Extensively revised, comprehensive content from leading global contributors ensures that
Hematology, 8th Edition, remains your# 1 choice for expert guidance in all areas of this …
Hematology, 8th Edition, remains your# 1 choice for expert guidance in all areas of this …
[HTML][HTML] Decoding human megakaryocyte development
Despite our growing understanding of embryonic immune development, rare early
megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA …
megakaryocytes (MKs) remain relatively understudied. Here we used single-cell RNA …
Lung megakaryocytes display distinct transcriptional and phenotypic properties
Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
The global burden of community-acquired pneumonia in adults, encompassing invasive pneumococcal disease and the prevalence of its associated cardiovascular …
R Anderson, C Feldman - International Journal of Molecular Sciences, 2023 - mdpi.com
Despite innovative advances in anti-infective therapies and vaccine development
technologies, community-acquired pneumonia (CAP) remains the most persistent cause of …
technologies, community-acquired pneumonia (CAP) remains the most persistent cause of …
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery
The present work aims to prove the concept of tumor-targeted drug delivery mediated by
platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the …
platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the …
Platelet aggregates, a marker of severe COVID-19 disease
A Rampotas, S Pavord - Journal of clinical pathology, 2021 - jcp.bmj.com
Thrombocytopenia is common in an intensive care unit (ICU) setting due to endogenous and
iatrogenic factors. Despite that, thrombocytopenia in patients with severe COVID-19 …
iatrogenic factors. Despite that, thrombocytopenia in patients with severe COVID-19 …
Long-lived lung megakaryocytes contribute to platelet recovery in thrombocytopenia models
AC Livada, KE McGrath, MW Malloy, C Li… - The Journal of Clinical …, 2024 - jci.org
Lung megakaryocytes (Mks) are largely extravascular with an immune phenotype (1).
Because bone marrow (BM) Mks are short lived, it has been assumed that extravascular …
Because bone marrow (BM) Mks are short lived, it has been assumed that extravascular …