Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications

AK Akobeng, P Singh, M Kumar… - European journal of …, 2020 - Springer
Purpose Although genetic predisposition and exposure to dietary gluten are considered
necessary triggers for the development of coeliac disease, alterations in the gut microbial …

The role of the microbiome in gastrointestinal inflammation

DJ Sanders, S Inniss, G Sebepos-Rogers… - Bioscience …, 2021 - portlandpress.com
The microbiome plays an important role in maintaining human health. Despite multiple
factors being attributed to the shaping of the human microbiome, extrinsic factors such diet …

Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation

N Steck, M Hoffmann, IG Sava, SC Kim, H Hahne… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Matrix metalloproteases (MMPs) mediate pathogenesis of chronic
intestinal inflammation. We characterized the role of the gelatinase (GelE), a …

Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis

A Schirbel, S Kessler, F Rieder, G West, N Rebert… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: In intestinal inflammation the gut microbiota induces an innate
immune response by activating epithelial and immune cells that initiate or maintain …

[HTML][HTML] Updated review on immune factors in pathogenesis of Crohn's disease

N Li, RH Shi - World Journal of Gastroenterology, 2018 - ncbi.nlm.nih.gov
Although the incidence of Crohn's disease (CD) in China is not as high as that in European
and American countries, there has been a clear increasing trend in recent years. Little is …

Bacterial-mucosal interactions in inflammatory bowel disease—an alliance gone bad

M Chichlowski, LP Hale - American Journal of Physiology …, 2008 - journals.physiology.org
The complex interaction of genetic, microbial, and environmental factors may result in
continuous activation of the mucosal immune system leading to inflammatory bowel disease …

Discerning the role of Bacteroides fragilis in celiac disease pathogenesis

E Sánchez, JM Laparra, Y Sanz - Applied and environmental …, 2012 - Am Soc Microbiol
Celiac disease (CD) is associated with intestinal dysbiosis, which can theoretically lead to
dysfunctions in host-microbe interactions and contribute to the disease. In the present study …

Gut microbiota in celiac disease: microbes, metabolites, pathways and therapeutics

KL Olshan, MM Leonard, G Serena… - Expert review of …, 2020 - Taylor & Francis
Introduction Current evidence supports a vital role of the microbiota on health outcomes,
with alterations in an otherwise healthy balance linked to chronic medical conditions like …

Intestinal Bacteroides species associated with coeliac disease

E Sánchez, E Donat, C Ribes-Koninckx… - Journal of Clinical …, 2010 - jcp.bmj.com
Aims To characterise the predominant species of bacterial populations associated with
duodenal biopsies of paediatric patients with active and treated coeliac disease. Methods 20 …

How to price fresh data

M Zhang, A Arafa, J Huang… - … Symposium on Modeling …, 2019 - ieeexplore.ieee.org
We introduce the concept of a fresh data market, in which a destination user requests, and
pays for, fresh data updates from a source provider. Data freshness is captured by the age of …