Ischemic stroke is a devastating condition that occurs due to the interruption of blood flow to
the brain, resulting in a range of cellular and molecular changes. In recent years, there has …

The facile abstraction of bis-allylic hydrogens from polyunsaturated fatty acids (PUFAs) is the
hallmark chemistry responsible for initiation and propagation of autoxidation reactions. The …

Hexanal and (E)-2-hexenal in soymilk mainly form during the soaking and grinding of
soybeans. In this study, freshly dehulled soybeans were soaked or ground in the presence …

Arachidonic acid (AA, 20: 4) is an omega-6 polyunsaturated fatty acid (PUFA) and the main
precursor to the class of lipid mediators known as eicosanoids. The enzymes that catalyze …

Human reticulocyte 15-lipoxygenase-1 (15-hLO-1) and human platelet 12-lipoxygenase (12-
hLO) have been implicated in a number of diseases, with differences in their relative activity …

Allosteric regulation of human lipoxygenase (hLO) activity has recently been implicated in
the cellular biology of prostate cancer. In the current work, we present isotope effect, pH, and …

Lipoxygenases (LOX) oxidize polyunsaturated fatty acids to hydroperoxides, which are
generated by proton coupled electron transfer to the metal center with Fe III OH− or Mn III …

Mammalian 15-lipoxygenases (15-LOs) are key pharmaceutical targets under strong
investigation because of their implication in atherosclerosis and cancer. Here, we present an …

A novel lipoxygenase (BLOX) was purified from black soybean (Glycine max (L.) Merr.), and
its catalytic properties were characterized. The molecular weight of BLOX was 101 kDa and …

Natural abundance deuterium 2D NMR spectroscopy in weakly ordering, polypeptide chiral
liquid crystals is a powerful technique that enables determination of enantiotopic isotopic …