The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier …

Aberrant gene function and altered patterns of gene expression are key features of cancer.
Growing evidence shows that acquired epigenetic abnormalities participate with genetic …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …

Calreticulin is a ubiquitous Ca2+ binding protein, located in the endoplasmic reticulum
lumen, which has been implicated in many diverse functions including: regulation of …

It has been almost a quarter century since it was first appreciated that a class of oncogenes
contained in rapidly transforming avian retroviruses encoded DNA-binding transcription …

The mechanisms regulating vertebrate heart and endoderm development have recently
become the focus of intense study. Here we present evidence from both loss-and gain-of …

Gene inactivation studies have shown that members of the GATA family of transcription
factors are critical for endoderm differentiation in mice, flies and worms, yet how these …

A combination of approaches has begun to elucidate the mechanisms of gastrointestinal
development. This review describes progress over the last 20 years in understanding …