3854 growth factors. The mitogen-activated protein kinases (MAPKs) play a major role in
mitogenic signaling, and the canonical Ras-Raf-MEK [MAPK and extracellular signal …

Rac GTPases, small G-proteins widely implicated in tumorigenesis and metastasis,
transduce signals from tyrosine-kinase, G-protein-coupled receptors (GPCRs), and integrins …

Summary While the small GTPase Rac1 and its effectors are well-established mediators of
mitogenic and motile signaling by tyrosine kinase receptors and have been implicated in …

Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin
cytoskeleton. They were originally thought to primarily affect cell migration and invasion; …

The Neuregulins and their receptors, the ErbB/HER subfamily of receptor tyrosine kinases,
have critical roles in animal physiology, and their deregulation is frequent in cancer. Here …

Background CXCL1 belongs to a member of the ELR+ CXC chemokine subgroups that also
known as GRO-alpha. It has been recognized that several types of human cancers …

Aims This study aims to explore the molecular mechanisms underlying sphingosine kinase 1
(SphK1) inducing pulmonary vascular remodeling and resveratrol suppressing pulmonary …

The number of Schwann cells is fitted to axonal length in peripheral nerves. This relationship
is lost when tumorigenic stimuli induce uncontrolled Schwann cell proliferation, generating …

Numerous studies exploring oncogenic Ras or manipulating physiological Ras signalling
have established an irrefutable role for Ras as driver of cell cycle progression. Despite this …

Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) representing∼ 85% of new diagnoses. The disease is often detected …