Fructose-containing sugars are a focus of attention as a public health target for their putative
role in obesity and cardiometabolic disease including diabetes. The fructose moiety is …

Obesity and metabolic syndrome are strongly associated with cancer, and these disorders
may share a common mechanism. Recently, fructose has emerged as a driving force to …

Glucokinase, a unique isoform of the hexokinase enzymes, which are known to
phosphorylate d-glucose and other hexoses, was identified during the past three to four …

Conversion of glucose into glycogen is a major pathway that contributes to the removal of
glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the …

The transfer of a phosphoryl moiety from ATP to an acceptor group is an essential step,
frequently the initial step, in the metabolism of many molecules. Hence, kinases represent a …

This clinical study was conducted to investigate the safety and effect of d-psicose on
postprandial blood glucose levels in adult men and women, including borderline diabetes …

Glucose is stored in mammalian tissues in the form of glycogen. Glycogen levels are
markedly reduced in liver or muscle cells of patients with insulin-resistant or insulin-deficient …

Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The
liver plays a key role in glucose homeostasis increasing or decreasing glucose output and …

Fructose has been shown to have a catalytic effect on glucokinase activity in vitro; however,
its effects on hepatic glycogen metabolism in humans is unknown. To address this question …

Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-
controlling step responsible for insulin stimulation of glycogen synthesis is unknown. We …