[HTML][HTML] Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training

CK Roberts, AL Hevener, RJ Barnard - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

AMPK in health and disease

GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior

RL Silverstein, M Febbraio - Science signaling, 2009 - science.org
CD36 is a membrane glycoprotein present on platelets, mononuclear phagocytes,
adipocytes, hepatocytes, myocytes, and some epithelia. On microvascular endothelial cells …

Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease

JFC Glatz, JJFP Luiken, A Bonen - Physiological reviews, 2010 - journals.physiology.org
Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

DE Kelley, B Goodpaster, RR Wing… - American Journal of …, 1999 - journals.physiology.org
The current study was undertaken to investigate fatty acid metabolism by skeletal muscle to
examine potential mechanisms that could lead to increased muscle triglyceride in obesity …

Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice

CT Coburn, FF Knapp, M Febbraio, AL Beets… - Journal of Biological …, 2000 - ASBMB
The transmembrane protein CD36 has been identified in isolated cell studies as a putative
transporter of long chain fatty acids. In humans, an association between CD36 deficiency …

[HTML][HTML] The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

R Sharon, I Bar-Joseph, MP Frosch, DM Walsh… - Neuron, 2003 - cell.com
Accumulation of misfolded proteins as insoluble aggregates occurs in several
neurodegenerative diseases. In Parkinson's disease (PD) and dementia with Lewy bodies …

Optimizing fat oxidation through exercise and diet

J Achten, AE Jeukendrup - Nutrition, 2004 - Elsevier
Interventions aimed at increasing fat metabolism could potentially reduce the symptoms of
metabolic diseases such as obesity and type 2 diabetes and may have tremendous clinical …

Transitions of muscle fiber phenotypic profiles

D Pette, RS Staron - Histochemistry and cell biology, 2001 - Springer
Skeletal muscle is a complex, versatile tissue composed of a large variety of functionally
diverse fiber types. The overall properties of a muscle largely result from a combination of …

Role of intramyocelluar lipids in human health

PM Coen, BH Goodpaster - Trends in Endocrinology & Metabolism, 2012 - cell.com
Intramyocellular lipid (IMCL) is predominantly stored as intramuscular triglyceride (IMTG) in
lipid droplets and is utilized as metabolic fuel during physical exercise. IMTG is also …