A Ciesielska, M Matyjek, K Kwiatkowska - Cellular and molecular life …, 2021 - Springer
Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro- inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …
Klebsiella species cause a wide range of diseases including pneumonia, urinary tract infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …
GC Brown - Journal of neuroinflammation, 2019 - Springer
The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting …
DM Chopyk, A Grakoui - Gastroenterology, 2020 - Elsevier
Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …
Pseudomonas aeruginosa is an opportunistic pathogen and the leading cause of mortality among immunocompromised patients in clinical setups. The hallmarks of virulence in P …
According to the hygiene hypothesis, the increasing incidence of autoimmune diseases in western countries may be explained by changes in early microbial exposure, leading to …
Vaccines containing novel adjuvant formulations are increasingly reaching advanced development and licensing stages, providing new tools to fill previously unmet clinical …
C Vaure, Y Liu - Frontiers in immunology, 2014 - frontiersin.org
Toll-like receptors (TLRs) belong to the pattern recognition receptor (PRR) family, a key component of the innate immune system. TLRs detect invading pathogens and initiate an …
JK Ryu, SJ Kim, SH Rah, JI Kang, HE Jung, D Lee… - Immunity, 2017 - cell.com
Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, binds Toll-like receptor 4 (TLR4)-MD2 complex and activates innate immune …