Franz diffusion cell and its implication in skin permeation studies
M Kumar, A Sharma, S Mahmood… - Journal of Dispersion …, 2024 - Taylor & Francis
Franz diffusion cell was primarily used to evaluate the permeability and stability of
formulations such as topical (gels and creams) and transdermal (lipid nanoparticle …
formulations such as topical (gels and creams) and transdermal (lipid nanoparticle …
Communication pathways to and from the inner ear and their contributions to drug delivery
AN Salt, K Hirose - Hearing research, 2018 - Elsevier
The environment of the inner ear is highly regulated in a manner that some solutes are
permitted to enter while others are excluded or transported out. Drug therapies targeting the …
permitted to enter while others are excluded or transported out. Drug therapies targeting the …
Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs
Background Inner ear diagnostics is limited by the inability to atraumatically obtain samples
of inner ear fluid. The round window membrane (RWM) is an attractive portal for accessing …
of inner ear fluid. The round window membrane (RWM) is an attractive portal for accessing …
Inner ear delivery: Challenges and opportunities
B Szeto, H Chiang, C Valentini, M Yu… - Laryngoscope …, 2020 - Wiley Online Library
Objectives The treatment of inner ear disorders remains challenging due to anatomic
barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent …
barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent …
Inner ear drug delivery: recent advances, challenges, and perspective
J Hao, SK Li - European Journal of Pharmaceutical Sciences, 2019 - Elsevier
Effective and safe treatment of auditory and vestibular diseases has become increasingly
dependent on inner ear drug delivery systems. This review highlights recent advances in …
dependent on inner ear drug delivery systems. This review highlights recent advances in …
Gene therapy for human sensorineural hearing loss
Hearing loss is the most common sensory impairment in humans and currently disables 466
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
Developing the supraparticle technology for round window-mediated drug administration into the cochlea
N Gunewardene, Y Ma, P Lam, S Wagstaff… - Journal of Controlled …, 2023 - Elsevier
The semi-permeable round window membrane (RWM) is the gateway to the cochlea.
Although the RWM is considered a minimally invasive and clinically accepted route for …
Although the RWM is considered a minimally invasive and clinically accepted route for …
Ultrasound microbubble–facilitated inner ear delivery of gold nanoparticles involves transient disruption of the tight junction barrier in the round window membrane
YC Lin, CP Shih, HC Chen, YL Chou… - Frontiers in …, 2021 - frontiersin.org
The application of ultrasound microbubbles (USMBs) enhances the permeability of the
round window membrane (RWM) and improves drug delivery to the inner ear. In this study …
round window membrane (RWM) and improves drug delivery to the inner ear. In this study …
Pharmacological Approaches to Hearing Loss
CR Cederroth, J Dyhrfjeld-Johnsen, B Canlon… - Pharmacological …, 2024 - Elsevier
Hearing disorders pose significant challenges to individuals experiencing them and their
overall quality of life, emphasizing the critical need for advanced pharmacological …
overall quality of life, emphasizing the critical need for advanced pharmacological …
In-vitro perforation of the round window membrane via direct 3-D printed microneedles
The cochlea, or inner ear, is a space fully enclosed within the temporal bone of the skull,
except for two membrane-covered portals connecting it to the middle ear space. One of …
except for two membrane-covered portals connecting it to the middle ear space. One of …