The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

Glucocorticoids (GCs) are small lipid hormones produced by the adrenals that maintain
organismal homeostasis. Circadian and stress-induced changes in systemic GC levels …

Pro-inflammatory cytokines that are generated by immune system cells and mediate many
kinds of immune responses are kinds of endogenous polypeptides. They are also the …

The secretion of glucocorticoids (GCs) is a classic endocrine response to stress. Despite
that, it remains controversial as to what purpose GCs serve at such times. One view …

▪ Abstract The transcription factor NF-κB has attracted widespread attention among
researchers in many fields based on the following: its unusual and rapid regulation, the wide …

Signs and symptoms that are characteristic for depression include changes in the setpoint of
the hypothalamic-pituitary-adrenocortical (HPA) system, which in the majority of these …

1. Glucocorticoids are widely used for the suppression of inflammation in chronic
inflammatory diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease …

Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved
are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF …

Glucocorticoids are potent immunosuppressive drugs, but their mechanism is poorly
understood. Nuclear factor kappa B (NF-κB), a regulator of immune system and inflammation …

A reciprocal regulation exists between the central nervous and immune systems through
which the CNS signals the immune system via hormonal and neuronal pathways and the …