Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …

Abstract Treatment for congenital adrenal hyperplasia (CAH) was introduced in the 1950s
following the discovery of the structure and function of adrenocortical hormones. Although …

An adrenal incidentaloma is now established as a common endocrine diagnosis that
requires a multidisciplinary approach for effective management. The majority of patients can …

Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Rhythms are intrinsic to endocrine systems, and disruption of these hormone oscillations
occurs at very early stages of the disease. Because adrenal hormones are secreted with …

Adrenarche is the maturational increase in adrenal androgen production that normally
begins in early childhood. It results from changes in the secretory response to …

Background: With the widespread use of advanced imaging technology, adrenal tumors are
increasingly being identified. Objective: To investigate the prevalence and characteristics of …

Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) usually present
bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol …