Biological aging processes underlying cognitive decline and neurodegenerative disease
MM Gonzales, VR Garbarino, E Pollet… - The Journal of …, 2022 - Am Soc Clin Investig
Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …
disability and mortality in later life. As with many chronic conditions, aging is the single most …
Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
The DNA methylation in neurological diseases
DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
Epigenetics of Alzheimer's disease
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
G-Quadruplexes as pathogenic drivers in neurodegenerative disorders
E Wang, R Thombre, Y Shah, R Latanich… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s), higher-order DNA and RNA secondary structures featuring
guanine-rich nucleic acid sequences with various conformations, are widely distributed in …
guanine-rich nucleic acid sequences with various conformations, are widely distributed in …
[HTML][HTML] Sex differences in Alzheimer's disease: insights from the multiomics landscape
Alzheimer's disease (AD) has complex etiologies, and the impact of sex on AD varies over
the course of disease development. The literature provides some evidence of sex-specific …
the course of disease development. The literature provides some evidence of sex-specific …
Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
NM Shanbhag, MD Evans, W Mao, AL Nana… - Acta neuropathologica …, 2019 - Springer
The maintenance of genomic integrity is essential for normal cellular functions. However, it is
difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA …
difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA …
The epigenetics of Alzheimer's disease: factors and therapeutic implications
X Liu, B Jiao, L Shen - Frontiers in genetics, 2018 - frontiersin.org
Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …
Targeting epigenetics: A novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …