A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

S Yu, VN Kim - Nature Reviews Molecular Cell Biology, 2020 - nature.com
RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

RNA surveillance by the nuclear RNA exosome: mechanisms and significance

K Ogami, Y Chen, JL Manley - Non-coding RNA, 2018 - mdpi.com
The nuclear RNA exosome is an essential and versatile machinery that regulates maturation
and degradation of a huge plethora of RNA species. The past two decades have witnessed …

Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation

J Lim, D Kim, Y Lee, M Ha, M Lee, J Yeo, H Chang… - Science, 2018 - science.org
RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and
decay. Guanylation of the poly (A) tail was discovered recently, yet the enzymology and …

mTOR-and LARP1-dependent regulation of TOP mRNA poly (A) tail and ribosome loading

K Ogami, Y Oishi, K Sakamoto, M Okumura… - Cell reports, 2022 - cell.com
Translation of 5′ terminal oligopyrimidine (TOP) mRNAs encoding the protein synthesis
machinery is strictly regulated by an amino-acid-sensing mTOR pathway. However, its …

An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression

K Ogami, P Richard, Y Chen, M Hoque… - Genes & …, 2017 - genesdev.cshlp.org
Many long noncoding RNAs (lncRNAs) are unstable and rapidly degraded in the nucleus by
the nuclear exosome. An exosome adaptor complex called NEXT (nuclear exosome …

Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism

Z Warkocki, V Liudkovska… - … of the Royal …, 2018 - royalsocietypublishing.org
In eukaryotes, almost all RNA species are processed at their 3′ ends and most mRNAs are
polyadenylated in the nucleus by canonical poly (A) polymerases. In recent years, several …

Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases

V Liudkovska, A Dziembowski - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Termini often determine the fate of RNA molecules. In recent years, 3′ ends of almost all
classes of RNA species have been shown to acquire nontemplated nucleotides that are …

Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome

B Hu, X Li, Y Huo, Y Yu, Q Zhang, G Chen, Y Zhang… - Scientific reports, 2016 - nature.com
Pathogen invasion triggers a number of cellular responses and alters the host transcriptome.
Here we report that the type of changes to cellular transcriptome is related to the type of …

3′ RNA uridylation in epitranscriptomics, gene regulation, and disease

MR Menezes, J Balzeau, JP Hagan - Frontiers in Molecular …, 2018 - frontiersin.org
Emerging evidence implicates a wide range of post-transcriptional RNA modifications that
play crucial roles in fundamental biological processes including regulating gene expression …

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

O Ziv, A Zeisel, N Mirlas-Neisberg, U Swain… - Nature …, 2014 - nature.com
Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is
carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing …