The treatment of the posterior-segment ocular diseases, such as age-related eye diseases
(AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the …

Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

Intravitreal administration is the method of choice in drug delivery to the retina and/or
choroid. Rabbit is the most commonly used animal species in intravitreal pharmacokinetics …

Endophthalmitis is an inflammatory reaction of intraocular fluids or tissues. Infectious
endophthalmitis is one of the most serious complications of ophthalmic surgery …

Purpose: To review the current state of evaluation and management of various forms of
endophthalmitis. Methods: A review of the literature is included, encompassing …

The aims of this research were to (1) create a curated universal database of intravitreal
volumes of distribution (V ss, ivt) and clearances (CL ivt) of small molecular weight …

Background: For the past two decades, there has been a huge expansion in the
development of therapeutic antibodies, with 6 to 10 novel entities approved each year …

Introduction: The review aims to discuss effects of vitrectomy on pharmacokinetics of anti-
vascular endothelial growth factor (anti-VEGF) agents, and attempt to provide treatment …

Management of postoperative bacterial endophthalmitis was explored in the
Endophthalmitis Vitrectomy Study 37 in 1995, which has underpinned the core protocols in …

Background The optimal management of patients with endophthalmitis is challenging and
includes both intravitreal and, in some cases, systemic antimicrobials. Systemic …