The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …

Haemolytic uraemic syndrome is a form of thrombotic microangiopathy affecting
predominantly the kidney and characterised by a triad of thrombocytopenia, mechanical …

Thrombotic microangiopathy can manifest in a diverse range of diseases and is
characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury …

Guidelines Committee and the sounding board of BSH. It was also placed on the members
section of the BSH website for comment. It has also been reviewed by Royal College of …

Background Chronic kidney disease (CKD) is estimated to affect 3% of pregnant women in
high-income countries,(Piccoli et al., 2018,# 13860) which equates to between 15,000 …

Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …

Pregnancy and postpartum are high-risk periods for different forms of thrombotic
microangiopathy (TMA). However, the management of pregnancy-associated TMA remains …

Abstract Thrombocytopenia develops in 5% to 10% of women during pregnancy or in the
immediate postpartum period. A low platelet count is often an incidental feature, but it might …

Eculizumab is the first and only medication approved for paroxysmal nocturnal
haemoglobinuria (PNH) and atypical haemolytic uraemic syndrome (aHUS) treatment …

Antiphospholipid syndrome (APS), an acquired autoimmune thrombophilia, is characterised
by thrombosis and/or pregnancy morbidity in association with persistent antiphospholipid …