Computational models in cardiology
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
The genetic basis of long QT and short QT syndromes: a mutation update
PL Hedley, P Jørgensen, S Schlamowitz… - Human …, 2009 - Wiley Online Library
Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …
abnormalities that are characterized by length perturbations of the QT interval as measured …
Molecular pathophysiology of congenital long QT syndrome
Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …
the fundamental cellular electrical event in the heart. The concerted function of these …
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
C Terrenoire, K Wang, KW Chan Tung… - Journal of General …, 2013 - rupress.org
Understanding the basis for differential responses to drug therapies remains a challenge
despite advances in genetics and genomics. Induced pluripotent stem cells (iPSCs) offer an …
despite advances in genetics and genomics. Induced pluripotent stem cells (iPSCs) offer an …
SCN5A Variants: Association With Cardiac Disorders
W Li, L Yin, C Shen, K Hu, J Ge, A Sun - Frontiers in physiology, 2018 - frontiersin.org
The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1. 5.
This channel predominates inward sodium current (INa) and plays a critical role in …
This channel predominates inward sodium current (INa) and plays a critical role in …
Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin
Summary Voltage-gated Na+(Na V) channels initiate neuronal action potentials. Na V
channels are composed of a transmembrane domain responsible for voltage-dependent …
channels are composed of a transmembrane domain responsible for voltage-dependent …
Crystallographic basis for calcium regulation of sodium channels
1649-Pos Board B419 Tailoring m-Conotoxin-KIIIA to Selectively Inhibit NaV1. 7 Jeff R.
McArthur, Gurpreet Singh, Denis McMaster, Robert Winkfein, D. Peter Tieleman, Robert J …
McArthur, Gurpreet Singh, Denis McMaster, Robert Winkfein, D. Peter Tieleman, Robert J …
Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1. 5
B Chagot, WJ Chazin - Journal of molecular biology, 2011 - Elsevier
The function of the human voltage-gated sodium channel NaV1. 5 is regulated in part by
intracellular calcium signals. The ubiquitous calcium sensor protein calmodulin (CaM) is an …
intracellular calcium signals. The ubiquitous calcium sensor protein calmodulin (CaM) is an …
Alternative paradigms for ion channelopathies: disorders of ion channel membrane trafficking and posttranslational modification
J Curran, PJ Mohler - Annual review of physiology, 2015 - annualreviews.org
Channelopathies are a diverse set of disorders associated with defects in ion channel (and
transporter) function. Although the vast majority of channelopathies are linked with inherited …
transporter) function. Although the vast majority of channelopathies are linked with inherited …
Crystal structures of Ca2+–calmodulin bound to NaV C-terminal regions suggest role for EF-hand domain in binding and inactivation
BR Gardill, RE Rivera-Acevedo… - Proceedings of the …, 2019 - National Acad Sciences
Voltage-gated sodium (NaV) and calcium channels (CaV) form targets for calmodulin (CaM),
which affects channel inactivation properties. A major interaction site for CaM resides in the …
which affects channel inactivation properties. A major interaction site for CaM resides in the …