Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

Malignant transformation and growth of the tumor mass tend to induce changes in the
surrounding microenvironment. Abnormality of the tumor microenvironment provides a …

Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms. Although AMPs have been essentially studied and developed as potential …

This paper discusses the role of peptides in cancer therapy with special emphasis on
peptide drugs which are already approved and those in clinical trials. The potential of …

Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

Highlights•PPIs that are dominated by a continuous epitope are amenable for inhibition.•A
significant share of PPIs contains such 'hot segments'.•Peptide-based inhibitors are obvious …

A novel cleavable amphiphilic peptide (CAP) was designed to be specifically responsive to
fibroblast activation protein‐α (FAP‐α), a protease specifically expressed on the surface of …

To assess the literature on preclinical and clinical efficacy and safety data of pharmacologic
groups proposed in the treatment of endometriosis, we performed a systematic review of …

Angiogenesis has become an attractive target for cancer therapy since the US Food and
Drug Administration (FDA) approved the first angiogenesis inhibitor (bevacizumab) for the …