Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …

Lymphatic structure and function play a critical role in fluid transport, antigen delivery, and
immune homeostasis. A dysfunctional lymphatic system is associated with chronic low …

Oxidative stress-mediated proliferation of vascular smooth muscle cells (VSMCs) contributes
to plaque formation and the progression of atherosclerosis. Polydatin is a derivative of …

Background Formononetin (FMN) is an isoflavone that produces arterial vasodilation.
However, the underlying molecular mechanisms are unclear. Purpose The purpose of this …

Age-Related Impairment of Structure and Function of Iliac Artery Endothelium in Rats Is
Improved by Elevated Fluid Shear Stress - PMC Back to Top Skip to main content NIH NLM …

Aging occurs with enhanced sympathetic nerve activity and endothelial dysfunction;
however, little is known of how successive branches of microvascular resistance networks …

The distribution of blood flow to skeletal muscle during exercise is altered with advancing
age. Changes in arteriolar function that are muscle specific underlie age‐induced changes …

Although CCN1 (also known as cysteine-rich, angiogenic inducer 61, CYR61) has been
reported to promote angiogenesis and neovascularization in endothelial cells (ECs), its …

Angiogenesis is the physiological process of capillary growth. It is strictly regulated by the
balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) …

Aging is a major risk factor in the development of cardiovascular diseases attributed to the
development of vascular endothelial dysfunction. Reduced bioavailability of endothelial …